DSpace Coleção:http://repositorio.ufgd.edu.br/jspui/handle/prefix/632023-11-27T11:14:02Z2023-11-27T11:14:02ZAnálise térmica dos complexos de lantânio e gadolínio com aceclofenaco sob condição não isotérmica: Com a determinação da energia de ativação por termogravimetriaMendoza, Laís da Silvahttp://repositorio.ufgd.edu.br/jspui/handle/prefix/57312023-09-20T05:06:34Z2022-09-03T00:00:00ZTítulo: Análise térmica dos complexos de lantânio e gadolínio com aceclofenaco sob condição não isotérmica: Com a determinação da energia de ativação por termogravimetria
Autor(es): Mendoza, Laís da Silva
Primeiro Orientador: Colman, Tiago André Denck
Abstract: The complexation of lanthanide metals with a class of drugs, the non-steroidal antiinflammatory drugs, may present promising drugs with great carcinogenic and bacterial biological activity. With the need to better understand the physical and chemical interactions of these new complexes, the objective of this work is to characterize two compounds of lanthanum and gadolinium with aceclofenac using Thermal Analysis by TGDSC curves and kinetic analysis of the compounds applying thermogravimetry. To carry out a bibliographic survey of recent articles that studied the kinetics of solid state reactions applying thermal analysis. The results obtained determined that the lanthanum compound is the least stable compared to the gadolinium compound, it also has a lower activation energy and a lower linearity. The gadolinium compound, in addition to having a higher activation energy, also has higher linearity, that is, the static model applied to the compounds was r2= 0.94 for the lanthanum compound and r2= 0.98 for the gadolinium compound. gadolinium, thus, the results of the characterization and the kinetic study performed were considered satisfactory.; La complejación de metales lantánidos con una clase de fármacos, los antiinflamatorios no esteroideos, puede presentar fármacos prometedores con alta actividad biológica cancerígena y bacteriana. Con la necesidad de comprender mejor las interacciones físico-químicas de estos nuevos complejos, el objetivo de este trabajo es caracterizar dos compuestos de lantano y gadolinio con aceclofenaco mediante análisis térmico por curvas TG-DSC y el análisis cinético de los compuestos aplicando termogravimetría. Realizar un levantamiento bibliográfico de artículos recientes que hayan estudiado la cinética de reacciones en estado sólido aplicando análisis térmico. Los resultados obtenidos determinaron que el compuesto de lantano es el menos estable en comparación con el compuesto de gadolinio, además tiene una menor energía de activación y una menor linealidad. El compuesto de gadolinio además de tener mayor energía de activación también presenta mayor linealidad, es decir, el modelo estático aplicado a los compuestos fue r2= 0.95 para el compuesto de lantano y r2= 0.98 para el compuesto de gadolinio, por lo tanto, los resultados de la caracterización y el estudio cinético realizado se consideraron satisfactorias.
Editor: Universidade Federal da Grande Dourados
Tipo: Dissertação2022-09-03T00:00:00ZMétodo simplificado para deposição de partículas de Óxido de prata em superfície de espuma de vidro via sonoquímicaSouza, Ana Caroline Dias dehttp://repositorio.ufgd.edu.br/jspui/handle/prefix/55832023-09-14T06:54:29Z2019-02-28T00:00:00ZTítulo: Método simplificado para deposição de partículas de Óxido de prata em superfície de espuma de vidro via sonoquímica
Autor(es): Souza, Ana Caroline Dias de
Primeiro Orientador: Sequinel, Thiago
Abstract: In this work a study is presented on the deposition of silver oxide in glass foams using ultrasonic bath. To meet the objectives, the appropriate conditions were studied to favor the addition of the oxide particles in the foam matrix. The parameters indicative of deposition were determined by X-ray diffraction analysis (XRD), chemical microanalysis by X-ray dispersive energy levels (EDS), X-ray fluorescence (FRX) and field emission scanning electron microscopy (FEG-MEV). The determination of the best deposition conditions was performed through factorial planning and surface response analysis. The analyzes carried out showed that the use of sonochemical allowed the deposition of silver oxide on the external and internal surfaces of glass foams. The results obtained in the factorial design indicate that the temperature and the mass of silver oxide directly influence the deposition. Evaluating the results of the response surface, it was determined that the best conditions for deposition were: temperature between 50 to 59 ºC, mass of Ag2O above 0,04 g and ultrasound time of 30 minutes. These results meet the objective of the work and reinforce the application of the foams, since the use of the deposition method attributed new advanced properties to glass foams.
Editor: Universidade Federal da Grande Dourados
Tipo: Dissertação2019-02-28T00:00:00ZDesenvolvimento de uma metodologia para redução de grupamentos nitro utilizando o catalisador Lacob-Pd4Silva, Sidne Rodrigues dahttp://repositorio.ufgd.edu.br/jspui/handle/prefix/51962023-09-14T06:46:14Z2022-03-18T00:00:00ZTítulo: Desenvolvimento de uma metodologia para redução de grupamentos nitro utilizando o catalisador Lacob-Pd4
Autor(es): Silva, Sidne Rodrigues da
Primeiro Orientador: Domingues, Nelson Luís de Campos
Abstract: Aromatic amines are valuable organic molecules that can be used in the synthesis of bioactive compounds, polymers, drugs, dyes and pharmaceuticals. However, it is worth mentioning that the traditional methods of obtaining these amines have been marked by major obstacles, due to the use of toxic solvents, long reaction times, high catalyst load, among other factors. In this context, reduction reactions via hydrogenation of the nitro group catalyzed by heterogeneous metallic catalysts based on Pd, Pt, Ni, Au, Fe, among others, have become a fast and efficient alternative for obtaining aromatic amines. However, many of these catalysts used in reduction reactions suffer from selectivity problems or need high temperatures to perform their functions. In this sense, the present work developed a methodology based on the principles of green chemistry, selective and efficient, for the reduction of nitro groups to amino used using a palladium-based catalyst (LACOB-Pd4). Therefore, after choosing the solvent (ethanol and water 1:1) and the reducing agent (NaBH4), the methodology was successfully applied to the reduction of nitrobiphenyls. The yields obtained ranged from 56 to >99% for a reaction time of five hours at room temperature, demonstrating the catalytic efficiency of LACOB-Pd4. Finally, the methodology was extended to different substrates (diphenyl ether, methyl benzoate, acetanilide, thiosalicylic acid derivatives, nitrostyrene and imino sugar) containing the nitro group, in order to evaluate the selectivity of the catalyst. The selectivity test results were positive with yields between 50 to >99%. However, it is worth noting that among the advantages of the developed methodology are: the use of ecologically sustainable solvents (a mixture of water/ethanol (1:1)), good yields (56 to >99%), short reaction time (5h), low amount of catalyst mass (0.001 to 0.002 mg) and reactions carried out at room temperature.
Editor: Universidade Federal da Grande Dourados
Tipo: Dissertação2022-03-18T00:00:00ZSíntese e propriedades fotofísicas de chalconas e tiocarbamoilpirazolinas pirenil-substituídasBughi, Douglas Henrique Corandinhttp://repositorio.ufgd.edu.br/jspui/handle/prefix/51952023-09-14T06:44:35Z2022-07-08T00:00:00ZTítulo: Síntese e propriedades fotofísicas de chalconas e tiocarbamoilpirazolinas pirenil-substituídas
Autor(es): Bughi, Douglas Henrique Corandin
Primeiro Orientador: Pizzuti, Lucas
Abstract: The present work presents the synthesis, structural characterization, spectroscopy, and evaluation of the biological activity of a series of five pyrenylchalcones and their subsequent conversion into 3-pyrenylpyrazolines by cyclo-condensation with thiosemicarbazide. For characterization of the two series of compounds, 1H and 13C nuclear magnetic resonance techniques, high-resolution mass spectrometry, melting point, UV-Vis spectroscopy, and fluorescence analysis were used. The synthetic route started with the synthesis of pyrazoline precursors, a series of pyrenylchalcones (3a-e), obtained from the Claisen-Schmidt condensation in an alkaline medium, of five para-substituted aromatic aldehydes (1a-e) with 1-acetylpyrene (2), with yields of 50-80%. Subsequently the precursors 3a-e were used as starting material to obtain the 3-pyrenylpyrazolines (5a-e) by cyclo-condensation with thiosemicarbazide (4) in an alkaline medium, with yields of 55-80%. Both structure and purity were confirmed by employing 1H and 13C NMR, HRMS, and melting point results. The absorption and fluorescence study of the structures were evaluated in DMF, Ether, CH2Cl2, MeCN, and MeOH as solvents and showed a change in absorption and fluorescence for the polar aprotic solvents. In the UV-Vis region, the compounds 3a-e showed bands with absorption maximum between 313 and 418 nm, and with emission maximum between 438-562 nm, after excitation at 350nm. The pyrazoline compounds 5a-e showed two absorption bands in the UV-Vis region with absorption maximum between 285-295 nm for the band I and 392-401 nm referring to the band II, when excited at 350 nm they emit bands between 435-475nm. In the in vitro biological assays, none of the analyzed compounds showed antimicrobial activity against the bacterial and fungal strains used in the methodology, presenting MIC values higher than 125 μg/mL, values out of the standards found in the literature for determining antimicrobial activity.
Editor: Universidade Federal da Grande Dourados
Tipo: Dissertação2022-07-08T00:00:00Z