Síntese, investigação estrutural e avaliação biológica de um novo complexo de Cu1 baseado em pirazolina 1,3,5-tri-substituída

Abstract

This paper presents a study related to the synthesis and structural characterization of a new complex of CuI pyrazoline-based linker 3-phenyl-5-(4-methoxyphenyl)-1thiocarbamoyl-4,5-di-hydro-1H-pyrazole. The new complex was obtained by the reaction of the precursor complex "[Cu(PPh3)Cl]" and their ligands in a ratio of 1: 1 by means of CH3CN/CH2Cl2. The complex was obtained as yellow crystals, and exhibit luminescence in the visible region of the UV when excited at 380 nm. The biological tests have shown that the complexes inhibit the growth of S. aureus (Gram-positive) and E. coli (Gram-negative). Full characterization of the synthesized complexes involves the technique of X-ray diffraction, CHN elemental analysis, IR spectroscopy, molecular absorption in the UV-Vis spectroscopy and emission (luminescence).