Síntese promovida por ultrassom e atividade antibacteriana de 4,5-diidro-1H-amidinopirazóis Tienil substituídos

Abstract

The present work describes the synthesis of 4,5-dihydro-1H-amidinopirazoles using sonochemical methodology by the cyclocondensation reaction of 3-aryl-1-(tien-2-yl)-prop-2-en-1-ones and aminoguanidine hydrochloride carried out in ethanol. Fourteen new molecules were synthesized, and, from these, thirteen were subjected to tests of antibacterial activity. The products were isolated in yields of 62-95%. The ultrasound-assisted synthesis has proved to be effective, since the reactions were carried out in less time and the products were obtained without using difficult purification procedures. The use of an environmentally friendly solvent, such as ethanol, favors further relations with green chemistry and collaborates with the environment by saving energy consumption, emission of volatile solvents in the atmosphere and the generation of toxic wastes. Some molecules showed highly selective results in the minimum inhibitory concentration and sensitivity test. From the pharmacological point of view, this fact is extremely important for obtaining substances with activity against certain microorganisms.