DSpace Communidade:http://repositorio.ufgd.edu.br/jspui/handle/prefix/562023-11-24T01:04:38Z2023-11-24T01:04:38ZAvaliação da prevalência de síndrome Burnout, marcadores metabólicos e associação com síndrome metabólica em trabalhadores da saúde do Hospital Universitário de Dourados - MSAssis, Jefferson Teodoro dehttp://repositorio.ufgd.edu.br/jspui/handle/prefix/52232023-09-14T06:44:05Z2022-09-08T00:00:00ZTítulo: Avaliação da prevalência de síndrome Burnout, marcadores metabólicos e associação com síndrome metabólica em trabalhadores da saúde do Hospital Universitário de Dourados - MS
Autor(es): Assis, Jefferson Teodoro de
Primeiro Orientador: Oesterreich, Silvia Aparecida
Abstract: Burnout syndrome (BS) is characterized as a three-dimensional syndrome in which the worker has emotional exhaustion, depersonalization, and low personal fulfillment. The cause of BS is usually associated with a response to chronic stress in the work environment. This study aimed to assess the prevalence of BS among workers at the University Hospital of Dourados and sought the factors associated with an increased risk of developing BS and other inflammatory syndromes related to the condition. The participants were 375 professionals, of whom 264 were directly involved in patient care, 94 were administrative assistants, and 17 were employees of the outsourced company that provides services to the hospital. For a better evaluation of the predictors, the participants were divided into two large groups: ME, which includes doctors, nurses, and nursing technicians, and NME Group, including administrative technicians and outsourced employees. Participants answered the following instruments: (1) Sociodemographic questionnaire; (2) Questionnaire for the assessment of Burnout Syndrome. For comparisons between the ME and NME groups, Student's t-test was used for the analysis of continuous variables and the chi-square test for categorical variables. The results indicated the prevalence of the SB profile in the ME group (11.5%) and the NME group (4.20%). Factors such as female gender, direct patient care, high workload, and night work may be associated with a propensity for BS among health workers at the University Hospital of Grande Dourados.
Editor: Universidade Federal da Grande Dourados
Tipo: Dissertação2022-09-08T00:00:00ZPrevalência da sarcopenia e a relação de seus componentes com a qualidade de vida de indivíduos em hemodiáliseCeloto, Bianca Raquel Bianchihttp://repositorio.ufgd.edu.br/jspui/handle/prefix/52222023-09-14T06:43:51Z2022-09-06T00:00:00ZTítulo: Prevalência da sarcopenia e a relação de seus componentes com a qualidade de vida de indivíduos em hemodiálise
Autor(es): Celoto, Bianca Raquel Bianchi
Primeiro Orientador: Spexoto, Maria Cláudia Bernardes
Abstract: End-stage chronic kidney disease (CKD) requires renal replacement therapy such as hemodialysis (HD), and this accelerates the onset of sarcopenia and can negatively influence the quality of life (QoL) of these individuals. Little is investigated about the components of sarcopenia considering the context of QoL of this population. Objectives: i) to assess the prevalence of sarcopenia in individuals aged 50 years or older with CKD on hemodialysis; ii) verify the association of sarcopenia with sociodemographic, clinical, anthropometric factors, sarcopenia components (muscular strength, skeletal muscle mass and physical performance) and QoL; iii) to correlate the components of sarcopenia determination with QoL. Methods: This is a cross-sectional study, with a non-probabilistic design, carried out at the Nephrology Center of Dourados, state of Mato Grosso do Sul, central-west region of Brazil, from January 2021 to January 2022. Participated individuals with CKD, aged 50 years or over, of both sexes and undergoing HD. Sociodemographic, clinical, functional, anthropometric, capacity, QoL and sarcopenia characteristics were investigated. For the diagnosis of sarcopenia, the algorithm and criteria proposed by the European Working Group on Sarcopenia in Older People (EWGSOP2) were adopted. Low muscle strength was determined at cut-off points for handgrip strength (HGS) <32 kg for men and <21 kg for women. Muscle mass was assessed in two methods, by calf circumference (CC) and by appendicular skeletal muscle mass index (ASMMI). Low muscle mass by CC was obtained at cutoff points ≤34 cm for men and ≤33 cm for women. And by the ASMMI <9.1 kg/m² for men and <6.6 kg/m² for women, both determined at the 20th percentile of the sample distribution. Low physical performance was determined by gait speed (GS) ≤0.8 m/s. QoL was assessed using the instrument proposed by the World Health Organization, the WHOQOL-bref (World Health Organization Quality of Life Instrument-bref). Descriptive statistics were performed and data were expressed as mean and standard deviation for continuous variables and percentages for categorical variables. Pearson's chi-square (χ2) was used for associations. Analysis of variance for the comparison of means between sarcopenia groups. Multiple comparisons were performed using the Tukey test. Pearson's correlation coefficient (r) was used to establish correlations between sarcopenia components and QoL. A significance level of 5% was adopted. Results: Of the 83 patients, there was a predominance of individuals with probable sarcopenia, both using CC (34.9%) and ASMMI (49.4%). Sarcopenia (confirmed and severe) was higher using CC than ASMMI (32.6% vs 18.1%). The mean age was 61.8 ± 8.3 years, most of them had low muscle strength (67.5%), adequate muscle mass obtained by both CC (55.4%) and ASMMI (79.5%) and adequate GS (71.1%). In the investigation of QoL, the physical domain (PD) had the lowest score (61.1±16.5). The median time of HD treatment in the study population was 26 months. There was no association between sarcopenia and global QoL as well as the domains evaluated. Significant associations were observed with weight (p<0.001), height (p=0.004), body mass index (BMI) (p<0.001), ASMMI (<0.001), HGS (<0.001) and GS (p=0.002) when sarcopenia was determined by the measure of CC. And when determined by the ASMMI, there was an association between sarcopenia and the variables weight (p<0.001), height (p=0.006), BMI (p<0.001), CC (<0.001), HGS (<0.001) and GS (p =0.002). Both HGS (p<0.05, r=0.25) and GS (p<0.001, r=0.36) were correlated with PD of the WHOQOL-bref instrument. Still, the GS was correlated with the ambient domain of the same instrument. Conclusion: The probable sarcopenia status was predominant and the PD was the most affected in this population. Individuals with sarcopenia had lower weight, BMI, CC and ASMMI compared to individuals with no sarcopenia and probable sarcopenia. The aspects of functionality, HGS and GS, determine the physical impairment in this population.
Editor: Universidade Federal da Grande Dourados
Tipo: Dissertação2022-09-06T00:00:00ZConsumo de alimentos ultraprocessados e obesidade em adultos no município de Dourados, MSSouza, Karoline Omizolo dehttp://repositorio.ufgd.edu.br/jspui/handle/prefix/51912023-09-14T06:44:45Z2022-03-28T00:00:00ZTítulo: Consumo de alimentos ultraprocessados e obesidade em adultos no município de Dourados, MS
Autor(es): Souza, Karoline Omizolo de
Primeiro Orientador: Fernandes, Ricardo
Abstract: The prevalence of obesity and non-communicable chronic diseases has increased worldwide, including in Brazil. Sedentary lifestyle habits and excessive consumption of energy-dense foods have been widely studied as risk factors. More recently, the study of food consumption according to the degree of food processing, as well as the association between the consumption of ultra-processed foods (UPF) and obesity has been highlighted in the scientific context. Studies that address the burden of chronic non-communicable diseases have revealed that diet is the modifiable factor that has the greatest impact on reducing morbidity and mortality, especially obesity, where UPF consumption appears to be an important harmful component to the health of the population at a global level. Therefore, the objective of this study was to assess whether UPF consumption was associated with obesity in the adult population in the city of Dourados, MS. Data on the consumption of these foods were collected through a 24-hour recall and anthropometric data (weight, height, and body mass index) to classify obesity. In this way, it was possible to analyze the association between the consumption of these foods and obesity, controlling for sociodemographic factors. Regression models were used to assess the association between UPF consumption participation (quartiles) and obesity. Foods classified as UPF had an average of 20.9% of total daily energy consumption. The increase in UPF consumption was associated with a greater chance of obesity in male individuals, adults aged 30 to 39 years and 50 to 59 years, of white skin color, of lower-income, and with low and high levels of education. Additional analyzes considering the potential effect of reverse causality due to the presence of chronic diseases, revealed statistically significant associations in the second quartile of UPF consumption, indicating an increase of 0.25 kg/m² in BMI for each increment of one percentage unit in the caloric contribution of UPF in the diet. In conclusion, the increase in UPF consumption may contribute to a greater chance of obesity in some sociodemographic strata, and to an increase in BMI. Public policymakers should consider actions that promote a reduction in UPF consumption.
Editor: Universidade Federal da Grande Dourados
Tipo: Dissertação2022-03-28T00:00:00ZInvestigação etnofarmacológica dos efeitos cardiovasculares e renais da Blutaparon portulacoides (A. Hil.) Mears em ratos espontaneamente hipertensosLeite, Patrícia Regina Terçohttp://repositorio.ufgd.edu.br/jspui/handle/prefix/51612023-09-14T06:34:09Z2021-12-15T00:00:00ZTítulo: Investigação etnofarmacológica dos efeitos cardiovasculares e renais da Blutaparon portulacoides (A. Hil.) Mears em ratos espontaneamente hipertensos
Autor(es): Leite, Patrícia Regina Terço
Primeiro Orientador: Gasparotto Junior, Arquimedes
Abstract: Systemic arterial hypertension (SAH) is a chronic, multifactorial and non-communicable disease, in which there is a persistent elevation of systolic and/or diastolic pressure ≥ 140 and/or 90 mmHg. Blutaparon portulacoides (A.St.-Hil.) Mears is a Brazilian plant species that is widely used in folk medicine. The present study investigated the cardiovascular and renal effects of aqueous extract of B. portulacoides (AEBP) against hypertension in spontaneously hypertensive rats (SHR). First, the herbaceous was collected for the preparation of the aqueous extract, for this, the whole plant (roots, stems and leaves) was used. In sequence, the chemical composition was analyzed by mass spectrometry in ultra performance liquid chromatography (ESI-MS). Then, acute toxicity was evaluated for 14 days in 10 female Wistar rats at 90 days of age. Then, after proving the safety of AEBP, prolonged diuresis was performed in 180-day-old rats, with 50 male SHR rats divided into 5 experimental groups (n=10) and 10 male Wistar-Kyoto rats (naive group), the animals were treated once a day for 28 days with different doses of AEBP extract (30, 100 and 300 mg/kg), hydrochlorothiazide (HCTZ; 25 mg/kg) and filtered water (negative control and naive: 10 ml/kg). The diuretic activity was evaluated on days 1, 14 and 28. In addition, the role of prostaglandins and cyclic nitric oxide potassium guanosine monophosphate (NO-cGMP-K+) in diuretic activity was also investigated, using 30 male SHR rats divided into 5 experimental groups (n=6) and 6 male Wistar-Kyoto rats (naive group), the animals received doses of indomethacin (5 mg/kg), L-nitro-arginine-methyl-ester (60 mg/kg), methylene blue (100 mg/kg), tetraethylammonium (10 mg/kg) and filtered water (NC and naive: 5 ml/kg), and after 1 hour they were treated with AEBP (300 mg/kg), HCTZ (25 mg/kg), and filtered water (CN and naive 0.2 ml/100 g). At the end of the treatments, the animals were submitted to the evaluation of electrocardiographic activity, systolic blood pressure (SBP), diastolic blood pressure (DBP), mean blood pressure (MAP) and heart rate (HR) by the direct method. Then, the mesenteric vascular bed (MVL) and the left kidney were isolated and prepared for perfusion to assess vascular reactivity to different concentrations of vasoactive substances (phenylephrine, angiotensin II, acetylcholine and sodium nitroprusside). In addition, blood samples were collected for serum biochemical analyses, as well as tissue samples from the aorta, heart and contralateral kidney, obtained to investigate the tissue antioxidant system, relative weight, cardiac morphometry and histology of the aforementioned tissues. Phytochemical analysis identified the presence of caffeic acid, ferulic acid and several flavonoids in the AEBP. As previously mentioned, the extract did not show toxicity or any sign of behavioral change was observed in Wistar rats. Finally, prolonged treatment with AEBP (300 mg/kg) induced significant diuretic activity in male rats by activating the NO-cGMP-K+ channel pathway. These effects reduced blood pressure and oxidative stress and prevented hypertension-induced renal vascular dysfunction and left ventricular hypertrophy.
Editor: Universidade Federal da Grande Dourados
Tipo: Dissertação2021-12-15T00:00:00Z