Avaliação do potencial antilitiasico do extrato etanólico das folhas da Persea americana Mill. em modelo experimental

Abstract

The use of medicinal plants is one of the oldest alternative ways of treating diseases; however, many of the species used have not been scientifically studied. The species Persea americana, popularly known as avocado, has wide dissemination in the Brazilian territory, occurring in the cerrado region of Mato Grosso do Sul. The leaves of this species are popularly used for the treatment of kidney stones and as a diuretic. Considering the popular use and its occurrence in the region of Grande Dourados, the present study aimed to verify the antilithiasis potential of Persea americana by evaluating its action in the prevention and treatment of bladder stones in foreign body model of bladder lithiasis in rats. Calcium oxalate (CaOx) pellets were implanted in the bladder of groups of rats. U-Control, U-EEPA P, U-EEPA T through microsurgery. The U-EEPA P and U-EEPA T groups were treated with the ethanolic extract of P. americana (EEPA) 250 mg / kg via gavage for 25 days. The U-EEPA P and U-EEPA T groups were treated with the ethanolic extract of P. americana (EEPA) 250 mg / kg via gavage for 25 days. At the end of the experiment, 24-hour urine was collected in a metabolic cage for volume, pH, density, urea and creatinine dosing, and serum was collected for calcium, magnesium, sodium, potassium, urea and creatinine dosages and tissues for histological analysis The U-control, U-EEPA P groups were sacrificed 30 days after the insertion of the pellet and the U-EEPA T group 55 days after. The growth of the calculations was measured by X-ray and measured by ruler. Results: Analysis of the calculations by X-ray did not indicate statistic difference in growth of the calculations between the test and control groups.