Síntese e caracterização de complexos de L-Glut.-Cu(II)/L-Glut.-Fe(III) e L-Asp.-Cu(II)/L-Asp.-(Fe(III) para controle de Aedes aegypti (Diptera: Culicidae)

Abstract

Dengue is a viral disease transmitted by the bite of female Aedes aegypti. DENV 1-4 have mosquitoes as vectors and the Aedes aegypti mosquito is a vector of the disease in Brazil. Dengue is the most serious public health problem worldwide. The insect control is accomplished by use of synthetic insecticides and / or biological. However, this form of control pushes the population of insects and induce resistance, making them ineffective products for insect control. The metallo-insecticides possess its bioactivity in the Cu (II) and Fe (III), these can be conveyed in the form of complexes for control of immature (eggs and larvae) A. aegypti. Although they are essential for the organisms, the metal ions have narrow range of toxicity "in vivo". The induction of redox reaction "in situ" (oxidative stress) using the insect and metabolism mediated by ions and / or metal complexes induces the formation of free radicals and oxidant species (ROS) to exercise toxicity / non-viability of the immature forms of A . aegypti. The compounds of coordination of Cu (II) and Fe (III) L-Glutamic acid and L-aspartic acid were synthesized, isolated, characterized, and their biological activity (larvicidal activity and bactericidal) evaluated. The results showed that L-Glutamate-Cu (II), L-Glutamate-Fe (III), L-Aspartate-Cu (II) and L-Asparto-Fe (III) have different biological activity to larvae (immature) A. aegypti with the following CL's respectively CL10 (6.75 ppm, 392.00 ppm, 31.42 ppm 1199.61 ppm) LC50 (53.40 ppm 1247.42 ppm, 100.25 ppm, 3415, 48ppm) and LC90 (ppm 423.50, 3780.06 ppm 319.82 ppm 9724.42 ppm). Studies have shown bactericidal activity of L-glutamate-Cu (II), L-Glutamate-Fe (III), L-Aspartate-Cu (II) and L-Asparto-Fe (III) to Gram-negative bacteria (Escherichia coli ) respectively with the MIC (2000 ppm does not inhibit 2000 ppm does not inhibit) Gram-positive (Staphylococcus aureus) respectively with the MIC's (500 ppm does not inhibit, 1000 ppm does not inhibit). Metal complexes (metallo-insecticide) can be used for the management of A. aegypti on all the complexes of Cu (II) as these can affect the immature forms of insects and microorganisms present in the breeding, participating in the food chain of the insect.