Síntese de diidropirimidinonas (DHPMs) utilizando catalisadores híbridos derivados de aminoácidos

Abstract

The synthesis of heterocyclic compounds containing in its structure nitrogen atoms, have played a key role in the pharmaceutical area because these molecules have as main characteristic diversity in the biological activity of which include: Anti-hypertensive activity, antitumor, anti-epileptic anti-inflammatory, anti HIV and others. The process for obtaining these compounds via multicomponent reaction is favored by high that convergence has, besides advantages such as high exploration power, atomic economy, easy availability of starting materials and is also considered an environmentally friendly reaction. The union between multicomponent reaction and heterogeneous catalysis makes the work of obtaining the compounds of interest, namely in this case 3,4 Diidropirimidinonas "environmentally friendly", since it involves the application of a catalyst in a separate step which can be easily removed from the reaction medium after the end of the reaction and it can be reused in subsequent syntheses thereby making the process cheaper. Thus to obtain 3.4 Dihydropyrimidinones by heterogeneous catalysis in multicomponent Biginelli reactions becomes combined in a large environmental concern because they have simple purification methods besides the use of less volatile solvents, making it a reaction that fits within the principles of green chemistry.