Teste in vitro de extrato de planta do cerrado (Gochnatia polymorpha) contra Mycobacterium tuberculosis, na busca de novas drogas contra a tuberculose

Abstract

INTRODUCTION: With the emergence of multidrug-resistant tuberculosis, there is an urgent need for new drugs to reduce the complexity and duration of treatment, and eradicate durable infections, in order to access it, the antimycobacterial activity of the ethanol extract of bark trunk Gochnatia polymorpha and standard drugs Isoniazid, Rifampicin, Streptomycin and Ethambutol was realized. METHODS: The study of the anti-M. tuberculosis was accessed by the reduction of resazurin methodology, where the color change of the indicator is directly proportional to the number of viable mycobacteria in the middle. We carried out research of MIC (minimum inhibitory concentration) of extract. RESULTS: The crude extract of Gochnatia polymmpha showed a MIC > 500pg/mL. CONCLUSION: The ethanol extract of Gochnatia polymorpha has showed no activity against Mycobacterium tuberculosis. Additional studies are needed to investigate other potential activities.