Efeito hipoglicemiante da Curatella americana L.

Abstract

Metabolic diases as diabetes and comorbidities associates are the fourth main cause of death in Brazil and one of the forms to minimize the health problems associates to these pathologies is a rigorous control of the glicemia. Diverse research has pointed organic systems that can be modulated by bioactives derived from plants for this end. Curatella Americana (Dilleneaceae) is a plant used in the popular medicine in cases of gastrointestinal riots, inflammations and assisting in the control of the glicemia. The objective of this work was to investigate the hipoglicemiante potential of the hydroalcoholic extract of leves of C. ameriana. The hydroalcoholic extract of leves of C. americana was prepared adding etanol 95% to the triturated product of the plant. After that one became fullfilled rotaevaporação, lyophilization and dissolution in Tween 80 a 1%. The antirust potential of the extract was investigated by the method of kidnapping of the radical 2,2+difenil+1+picril+hidrazila (DPPH). For the alive study in, had been used 10 adult rats Wistar, 10 months of life, distributed in the groups: C. Americana (200 mg/kg, n=5) and Control (Tween 80 1%, n=5) treated daily for gavagem during 12 days. They had been evaluated the evolution of the corporal mass, in grams of glucose, using themselves the device Accu-chek Active – hematological parameters, using the automatic blood cells analyzer (KX-21-N-Sysmex, Roche®). The results shower the antioxidant activity of hydroalcoholic extract of C. Americana and it action in reducing blood glucose, as well as, the body mass of animals treated with the same. There were not observed signs of toxicity according to the parameters hematological and liver-related evaluated. Together, ours results confirm the potential hypoglycemic of hydroalcoholic extrac of C. Americana problaby mediated by its antioxidant action.