Caracterização química e atividades biológicas de Bauhinia rufa (Bong.) Steud. e Schinus terebinthifolius Raddi

Abstract

Medicinal plants are used to treat various diseases, including diabetes and infections, which are determining factors in increasing public health expenditures and reducing the quality of life of these people. In this perspective, was created a National List of Medicinal Plants of Interest to the Unified Health System (RENISUS) for to estimulate the development of new drugs. Bauhinia rufa (Bong.) Steud. and Schinus terebinthifolius Raddi are medicinal plants whose genus are part of RENISUS list. In this context, the objective of this study was to evaluate the chemical composition and the biological activities of B. rufa and S. terebinthifolius. The chemical profile and the biological activities of the methanolic extract of the leaves of B. rufa (MEBr), the methanolic extracts from roots, stem bark and leaves (MESL) of S. terebinthifolius and the ethyl acetate extracts of isolated endophytic fungi of fruits, stem bark and roots of S. terebinthifolius were evaluated. The biological activities evaluated include control of redox balance, glycemic and bacterial. In summary, the main results indicate that all the extracts characterized presented phenolic compounds and antioxidant activity. MEBr and MESL presented potential on glycemic control, additionally they were not toxic at the concentrations evaluated. The extract of the endophytic fungus Ochrocladosporium elatum of the fruits of S. terebinthifolius showed antibacterial activity against bacteria Staphylococcus aureus, Klebsiella pneumonia and Salmonella enteritidis. In conclusion, the results of this study indicate biological activities of different extracts of B. rufa, S. terebinthifolius and the endophytic fungus Ochrocladosporium elatum isolated from this plant, indicating promising natural resources in the control of redox balance, glycemic and bacterial. Finally, we emphasize that this thesis will be presented through a brief introduction, literature review and three scientific articles generated by the data obtained.