Efeitos da irradiação do sangue intravascular com laser associado a estimulação transcraniana por corrente continua em individuos com fibromialgia: ensaio clinico randomizado triplo cego

Abstract

Background: Fibromyalgia (FM) is a syndrome characterized by chronic widespread musculoskeletal pain, often associated with sleep disturbances, fatigue, and significant impacts on quality of life. Recent studies have explored neuromodulatoryinterventions such as transcranial direct current stimulation (ETCC), which modulates cortical excitability, and intravascular laser irradiation of blood (ILIB), known for combating free radicals and alleviating pain. Despite growing interest, data on the combined efficacy of these approaches in FM patients remain limited.Justification: Given the debilitating impact of FM and the need for safe and effective therapies, this study aims to address gaps in the literature by evaluating the combined effects of ETCC and ILIB. The findings could contribute to the development of new therapeutic strategies, particularly for patients unresponsive to conventional treatments.Objectives: To investigate the effects of ten sessions of active ETCC combined with ILIB on pain reduction, quality of life, and physical function in FM patients, comparing outcomes across different application protocols.Methods: This randomized, triple-blind clinical trial included participants diagnosed with FM,divided into four experimental groups: GEA (active ETCC + ILIB), GES (sham ETCC + ILIB), GEL (ILIB only), and GC (ILIB off). The ETCC protocol followed the 13:20:13 model with 2 mA intensity, while ILIB employed a 660 nm red laser applied to the wrist. Interventions were administered in 10 sessions over two weeks. Pain scales, quality of life measures, and pressure algometry were assessed before, after 5 and 10 sessions, and 30 days post-treatment.