Estudo de novos catalisadores heterogêneos nas sínteses multicomponentes de β-enaminonas e 1,4-diidropiridina em ultrassom

Abstract

Multi component Reactions (MCR) are defined as reactions where more than two components react to form the product, incorporating essentially all, or at least most of the atoms of the starting materials. This allows this reaction to fit into the concept of atom economy, associating a simple synthetic procedures to minimise the formation of by-products. As a consequence, this process reduces costs and duration of the reactions and also represents an efficient one-pot process to build complex molecules. For these reasons above, the MCRs are superior tools for organic synthesis compared to classical chemical reactions, in which only one or two starting materials are united to form the product, following the principles of the Green chemistry. The use of heterogeneous catalysts (metal complexes and nanoparticles) and ultrasound in the development of MCR have been the subject of growing interest among research groups. In the attempt to develop a new synthetic methodology, more efficient and environmentally correct, it was used such multi-component catalysts in reactions for the synthesis of β- enaminones which is a class of important mediators in the synthesis of heterocycles and 1,4 - Dihydropyridines that present a broad spectrum of biological and pharmacological activity.