Síntese, caracterização, atividade antineoplásica e catalítica de complexos de níquel (II) derivados de Bases de Schiff

Abstract

Schiff bases are also known as imines and belong to a class of organic compounds having in their molecular structure a functional group which contains a double bond between carbon and nitrogen (C=N), and are obtained by the condensation of an aldehyde with primary amine. The Schiff bases are widely employed as ligands. The interest in developing and characterization of the complexes containing asymmetric Schiff bases ligands with transition metal ions is justified by the presence of these structures in natural systems. There are some applications of these complexes like in catalytic reactions and biological assays. It was seen that the biological active compounds may increase their activities upon chelation with metal ions. The range of possible metal complexes with Schiff bases with large variety of ligands coordinating favors the development of this research, moreover, there are a lot of applications of these materials. The electronic configuration of nickel is 4s2 3d8 and which form many complexes that usually are square-planar or octahedral. This paper aims the synthesis, characterization and potential applications of nickel iminic complex. The results showed that mass spectra confirmed the molecular weights of the ligands. The UV-Vis spectra showed bands assigned to the transitions π-π* and n-π* in the ligands that shifted in the complexes. FTIR spectra and patterns of X-ray diffraction provided evidence of complexation of the ligand with nickel ion. The complex Ni_Salan induced cell death in cultures of cells of human chronic myeloid leukemia (CML) and human and rat tumor cell hepatic. The complexes Ni_Salan, Ni_Salan (NO2) and Ni_Salan (MeO) catalysed reaction aza-Diels Alder reaction.