Síntese, caracterização e estudo da reatividade de salicilatos e benzoatos de alquila resorcinólicos com íons metálicos

Abstract

Aiming to obtain substances with pharmacological and insecticidal potential (larvicidal activity against Aedes Aegypti), this work presents a study about the reactivity of resorcinolic and analogous benzoic acids for the formation of complexes with metallic ions, especially focusing copper, highlighting the potentiation of its biological activities. Several complexation methods were tested for varying the reactional conditions. In the tested conditions, we did not observe any reactivity of the copper ion (II) with the resorcinolic esters. However, we observed reactivity of the copper ion (II) with salicylic, benzoic, 3,5-dihydroxybenzoic and 3,5-dimethoxybenzoic acids. The characterization of the complexes obtained was performade by IR and Uv-vis. Therefore some complementary analyzes in order to structurally propose these complexes are needed. The synthesis of an unpublished complex of Ag(I) with triphenylphosphine and potassium thiocyanate ligands is also described. The characterization and the structure of the complex were made through IR and X-ray diffraction. This substance is being investigated for its antitumoral activity.