Síntese e caracterização de complexos metálicos baseados em cobre-aminoácidos para avaliação da atividade larvicida em Aedes Aegypti (Diptera: culicidae)

Abstract

Dengue is an arbovirus that has high incidence in tropical countries and recently is of worsening increasing in (sub)tropical countries. The dengue’s transmitter (Aedes agypti) control is mainly based on the use of conventional chemical insecticides such as organophosphates, pyrethroids, among others. Excessive and continuous application of these insecticides enabled resistance insect vector’s development, therefore, monitoring and resistance management are elements that should be considered. In this context, were evaluated the toxic activity of copper complexes with amino acids tryptophan, histidine, methionine and taurine on Aedes aegypti, Rockefeller strain. Among the complexes, only the CuII-Taurine showed strong toxic activity allowing 100% of mortality within 24 hours in the lowest concentration being 50 ppm. The complex CuII-Histidine didn’t show any larvicidal activity at the tested concentrations to 1000 ppm. For CuII-Tryptophan and CuII-Methionine complexes, the percentages of mortality ranged from 3.16% to 46.55% and 5.46% to 12.42% respectively. Considering the concentration of 1000 ppm for 24 hours of exposure to the larvae complexes can be proposed the following of toxicity series. The toxicity series to metal-amino acid is: CuII-Taurine >> CuII-Tryptophan > CuII-Methionine >>> CuII-Histidine.