Associação entre o fenótipo cintura hipertrigliceridêmica e diabetes mellitus em adultos: um estudo de casos e controles

Abstract

Cardiovascular diseases (CVD) are the leading cause of death in the world. Diabetes mellitus (DM) contributes significantly to CVD incidence, and is among the top 10 causes of death worldwide being considered as a public health problem. The objective of this study was to analyze the association between the hypertriglyceridemic waist phenotype and DM in the adult population of Dourados - MS, Brazil. This is a case-control study nested in a population-based study titled "Prevalence of Systemic Arterial Hypertension and Associated Factors in Adults of Golden-MS." The data analyzed correspond to a sample of adults of both sexes, including 293 individuals from 20 to 59 years old, being 56 cases and 237 controls. Among the variables studied were: DM, hypertriglyceridemic waist phenotype (CHT), sociodemographic and behavioral variables. DM was defined as fasting glycemia ≥126 mg / dL or self-referred in an applied questionnaire. The CHT phenotype defined as individuals who presented waist circumference (WC): ≥ 80 cm for women and ≥ 90 cm for men, combined with hypertriglyceridemia (TG) ≥ 150 mg / dL). Data were analyzed using SPSS 21.0 software. The chi-square test and Fisher's exact test were used to determine the distribution of characteristics and logistic regression models were used to calculate odds ratios (OR), and their 95% confidence intervals (CI), with statistical significance P < 0.05. After adjusting for covariates, age and CHT phenotype, they were significantly associated with DM (OR: 7.530, 95% CI: 2.539-22.172, OR: 2.075, 95% CI: 1.044-4.12), respectively). Females had DM protection (OR: 0.482, 95% CI: 0.248-0.937). The study suggests that the CHT phenotype can be used as an approach in the identification of DM.