Análise preliminar da atividade citoprotetora de Campomanesia adamantium (Cambess.) O. Berg, Alibertia edulis (L. C. Rich.) A. Rich E Schinus terebinthifolius Raddi em dois modelos de indução de úlceras gástricas

Abstract

Peptic ulcers affect about 10% of the world population and are characterized by lesions in the gastric and duodenal mucosae, induced by the imbalance between protective and aggressive factors of the mucosa. Due to its recurrence, agents that promote its eradication have been increasingly investigated, including the use of medicinal plants. The aim of this study was to evaluate the cytoprotective effect of aqueous extracts from the leaves of Campomanesia adamantium (CA), Alibertia edulis (AE) and Schinus terebinthifolius (ST) in ethanol-induced and non-steroidal anti-inflammatory (NSAID) acute ulcer models. The CA species is known to have rich amounts of flavonoids and glycoflavonoids; AE has alkaloids, iridoid triterpenes, saponins, flavonoids, steroids and anthraquinones and ST stands out for the presence of simple phenolic compounds, flavonoids and tannins, essential oil, steroids, triterpenes, anthraquinones and saponins. The yields of aqueous extracts of CA, AE and ST were 5.461; 12.444 and 10.474% respectively. The ulcerative activity of the three plant extracts was induced on the model with ethanol and NSAID, and in the ethanol model, all of them showed results significantly favorable to gastroprotection of the gastric mucosa by the Tukey test, with a confidence interval of 0.05%. In the NSAID model, it was not possible to safely verify the potential of the extracts, since the ulcer was not efficiently induced by indomethacin.