Análise da toxicidade aguda de Cecropia pachystachya Trécul e Cuphea calophylla Cham. & Schltdl em ratos Wistar

Abstract

The use of medicinal plants by the Brazilian population is a common and ancient practice, due to the great biodiversity throughout the national territory, several species are used in the treatment of different diseases. Cecropia pachystachya Trécul, popularly known as embaúba and Cuphea calophylla Cham. & Schltdl, known as Sete sangrias are two species used for various curative purposes in popular medicine, but until now, their pharmacological safety has not been evaluated. Taking this in consideration, the aim of this study was to investigate the acute oral toxicity (TOA) of these species using protocol No. 425 of the OECD. Aqueous extracts of the two species called ESCP and ESCC were used. Three groups of female Wistar rats were divided into five animals each and received 2000 mg / kg of ESCP, or ESCC or water (5 mL / kg Control). For 14 days the animals were weighed and the consumption of water and food was evaluated. On the 15th day, the animals were euthanized and the vital organs were evaluated macro and microscopically. The study indicated that the use of ESCP or ESCC at a concentration of 2000mg / kg did not present acute oral toxicity in the animal model used. We conclude that the present study showed pharmacological safety of these extracts in this study model, opening the way for further studies in terms of pharmacological safety to be carried out.