Potencial antiglicação do extrato aquoso da Smilax fluminensis Steud. e seu efeito sobre o metabolismo animal submetidos a dieta hipercalórica

Abstract

Diabetes mellitus is a disease of multiple etiology, whose common consequence is hyperglycemia, with wide and alarming global growth and a public health problem in several countries. Smilax fluminensis Steud. is a species popularly used in the treatment of various inflammatory diseases, and hypoglycemic activity has been identified. The objective of this study was to evaluate the inhibition potential of the formation of advanced glycation end products (AGEs) in an in vitro model, as well as to evaluate the effect on in vivo metabolism of rats submitted to a hypercaloric diet aqueous extract from S. fluminensis leaves. Weight gain, glycemia and epididymal fat were analyzed in the in vivo test after 8 weeks of treatment with extract. The results showed that the aqueous extract of S. fluminensis had a significant inhibitory potential for AGE formation, but the in vivo model used did not allow us to evaluate the effect of this species in vivo.